Reduced steroid activation of elephant shark GR and MR after inserting four amino acids from the DNA-binding domain of lamprey corticoid receptor-1

Atlantic Hose Sink Hook sea lamprey contains two corticoid receptors (CRs), CR1 and CR2, that have identical amino acid sequences, except for a four amino acid insert (Thr-Arg-Gln-Gly) in the CR1 DNA-binding domain (DBD).Steroids are stronger transcriptional activators of CR2 than of CR1 suggesting that the insert reduces the transcriptional respon

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The Fourth Industrial Revolution: Conceptual paradox or catalyst for achieving the Sustainable Development Goals?

The topic of the Fourth Industrial Revolution (4IR) became significant in South Africa from 2017, Hose Sink Hook through advocacy, amongst others, by the University of Johannesburg and subsequently through the appointment of the Presidential Commission on 4IR.Preceding industrial revolutions each focused on a single technology; 4IR, however, speaks

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Extracts of Knoxia roxburghii (Spreng.) M. A. Rau Induce Apoptosis in Human MCF-7 Breast Cancer Cells via Mitochondrial Pathways

Knoxia roxburghii (Spreng.) M.A.Rau (KR) is a plant clinically used in traditional Chinese medicine (TCM) for the treatment of cancer.The study objectives were to examine the effects of KR extracts, petroleum ether (PET), ethyl acetate (EtoAc), butanol (n-BuOH), and H2O-soluble fractions (HSF) of the 75% EtOH extraction on A549 (non-small cell lung

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Beyond Governance: Political Consolidation and Community Engagement in Union Parishad Standing Committees, Bangladesh

This study examines the operational functionality of Union Parishad (UP) Standing Committees (SCs) in Bangladesh, with a focus on their Fuel Delivery:Air Intake roles in local governance and political consolidation.This qualitative study purposively selected 48 participants, comprising representatives from the UP, government officials, NGO represen

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